APOE-based models of "pre-dementia"

Journal Article (Journal Article)

Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding the etiology and progression of late-onset Alzheimer's disease (AD). Unfortunately, no such model exists. Herein, I review all past and present attempts to create an APOE-based model with suggestions on how to reproduce AD in a mouse. Our ability to succeed in recreating late-onset AD will depend on the identification of new genetic markers in addition to the validation of nongenetic factors thought to increase the risk of dementia. These new factors can then be incorporated into an APOE-expressing animal for mechanistic studies and identification of new drug targets. © 2011 Springer Science+Business Media, LLC.

Full Text

Duke Authors

Cited Authors

  • Sullivan, PM

Published Date

  • January 11, 2011

Published In

Volume / Issue

  • 48 /

Start / End Page

  • 439 - 447

Electronic International Standard Serial Number (EISSN)

  • 1940-6045

International Standard Serial Number (ISSN)

  • 0893-2336

Digital Object Identifier (DOI)

  • 10.1007/978-1-60761-898-0_22

Citation Source

  • Scopus