A ceramide-centric view of insulin resistance.


Journal Article

The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of physiological processes and as a critical modulator of cellular stress. In this review, we discuss from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases. Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance.

Full Text

Cited Authors

  • Chavez, JA; Summers, SA

Published Date

  • May 2012

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 585 - 594

PubMed ID

  • 22560211

Pubmed Central ID

  • 22560211

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

International Standard Serial Number (ISSN)

  • 1550-4131

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2012.04.002


  • eng