Ceramides as modulators of cellular and whole-body metabolism.

Published

Journal Article (Review)

Nearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites. While the role of these lipids in the regulation of cell growth and death has been studied extensively, recent studies suggest that a primary consequence of ceramide accumulation is an alteration in metabolism. In both cell-autonomous systems and complex organisms, ceramides modify intracellular signaling pathways to slow anabolism, ensuring that catabolism ensues. These ceramide actions have important implications for diseases associated with obesity, such as diabetes and cardiovascular disease.

Full Text

Cited Authors

  • Bikman, BT; Summers, SA

Published Date

  • November 2011

Published In

Volume / Issue

  • 121 / 11

Start / End Page

  • 4222 - 4230

PubMed ID

  • 22045572

Pubmed Central ID

  • 22045572

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI57144

Language

  • eng