Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants

Journal Article

Fetal lung produces corticotropin-releasing hormone (CRH) without known direct effects. We tested the hypothesis that CRH can directly regulate lung development. In baboon fetal lung explants, CRH strongly induces surfactant phospholipid synthesis and SP-C immunostaining, plus [3H]thymidine incorporation. CRH receptor mRNA was detected in lung from multiple baboons at e125. Testing thyrotropin (TRH) as a specificity control, we did demonstrate different direct effects with only modest stimulation of surfactant phospholipid synthesis and strong induction of cytidylyltransferase gene expression. Therefore, CRH, similar to ACTH and glucocorticoids, is a potent inducer of cell differentiation in fetal lung. © 2000 Published by Elsevier Science Inc.

Duke Authors

Cited Authors

  • Emanuel, RL; Torday, JS; Asokananthan, N; Sunday, ME

Published Date

  • 2001

Published In

  • Peptides

Volume / Issue

  • 22 / 12

Start / End Page

  • 1819 - 1829