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Pregnancy outcomes associated with viral hepatitis.

Publication ,  Journal Article
Reddick, KLB; Jhaveri, R; Gandhi, M; James, AH; Swamy, GK
Published in: J Viral Hepat
July 2011

The aim of this study was to examine the contribution of hepatitis B virus (HBV) and hepatitis C virus (HCV) to pregnancy-related complications including gestational diabetes mellitus (GDM), preterm birth (PTB), intrauterine growth restriction (IUGR), pre-eclampsia, antepartum haemorrhage and cholestasis. The Nationwide Inpatient Sample was queried for all pregnancy-related discharges, pregnancy complications and viral hepatitis from 1995 to 2005. Logistic regression was used to examine the association between HBV, HCV, HBV + HCV and pregnancy-related complications including GDM, PTB, IUGR, pre-eclampsia, antepartum haemorrhage, cholestasis and caesarean delivery. Model covariates included maternal age, race, insurance status, substance use and medical complications including liver complication, hypertension, HIV, anaemia, thrombocytopenia and sexually transmitted infections. Of 297 664 pregnant women data available for analysis, 1446 had a coded diagnosis of HBV, HCV or both. High-risk behaviours, such as smoking, alcohol and substance use were higher in women with either HBV or HCV. Women with HBV had an increased risk for PTB (aOR 1.65, CI [1.3, 2.0]) but a decreased risk for caesarean delivery (aOR 0.686, CI [0.53, 0.88]). Individuals with HCV had an increased risk for GDM (aOR 1.6, CI [1.0, 2.6]). Individuals with both HBV and HCV co-infection had an increased risk for antepartum haemorrhage (aOR 2.82, CI [1.1, 7.2]). There was no association of viral hepatitis with IUGR or pre-eclampsia. Women with hepatitis have an increased risk for complications during pregnancy. Research to determine the efficacy and cost-effectiveness of counselling patients about potential risks for adverse outcomes is warranted.

Duke Scholars

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

July 2011

Volume

18

Issue

7

Start / End Page

e394 / e398

Location

England

Related Subject Headings

  • Risk Factors
  • Premature Birth
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Pre-Eclampsia
  • Infant, Newborn
  • Humans
  • Hepatitis C
  • Hepatitis B
 

Citation

APA
Chicago
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MLA
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Reddick, K. L. B., Jhaveri, R., Gandhi, M., James, A. H., & Swamy, G. K. (2011). Pregnancy outcomes associated with viral hepatitis. J Viral Hepat, 18(7), e394–e398. https://doi.org/10.1111/j.1365-2893.2011.01436.x
Reddick, K. L. B., R. Jhaveri, M. Gandhi, A. H. James, and G. K. Swamy. “Pregnancy outcomes associated with viral hepatitis.J Viral Hepat 18, no. 7 (July 2011): e394–98. https://doi.org/10.1111/j.1365-2893.2011.01436.x.
Reddick KLB, Jhaveri R, Gandhi M, James AH, Swamy GK. Pregnancy outcomes associated with viral hepatitis. J Viral Hepat. 2011 Jul;18(7):e394–8.
Reddick, K. L. B., et al. “Pregnancy outcomes associated with viral hepatitis.J Viral Hepat, vol. 18, no. 7, July 2011, pp. e394–98. Pubmed, doi:10.1111/j.1365-2893.2011.01436.x.
Reddick KLB, Jhaveri R, Gandhi M, James AH, Swamy GK. Pregnancy outcomes associated with viral hepatitis. J Viral Hepat. 2011 Jul;18(7):e394–e398.
Journal cover image

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

July 2011

Volume

18

Issue

7

Start / End Page

e394 / e398

Location

England

Related Subject Headings

  • Risk Factors
  • Premature Birth
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Pre-Eclampsia
  • Infant, Newborn
  • Humans
  • Hepatitis C
  • Hepatitis B