Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1.
Publication
, Journal Article
Martin, D; Swartzwelder, HS
Published in: Eur J Pharmacol
September 4, 1992
Slices of hippocampal area CA1 were employed to test the hypothesis that release of excitatory amino acids glutamate and aspartate is regulated by ethanol. K(+)-evoked release of glutamate and aspartate was inhibited by ethanol (25-100 mM) in a dose-dependent manner. Ethanol (100 mM) also inhibited K(+)-evoked gamma-aminobutyric acid release. This selective inhibition of excitatory amino acid release by ethanol may contribute to some of the learning and memory deficits associated with ethanol abuse, since excitatory amino acid receptors play an important role in synaptic plasticity processes.
Duke Scholars
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
September 4, 1992
Volume
219
Issue
3
Start / End Page
469 / 472
Location
Netherlands
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Potassium
- Pharmacology & Pharmacy
- In Vitro Techniques
- Hippocampus
- Glutamic Acid
- Glutamates
- Female
- Ethanol
Citation
APA
Chicago
ICMJE
MLA
NLM
Martin, D., & Swartzwelder, H. S. (1992). Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. Eur J Pharmacol, 219(3), 469–472. https://doi.org/10.1016/0014-2999(92)90491-l
Martin, D., and H. S. Swartzwelder. “Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1.” Eur J Pharmacol 219, no. 3 (September 4, 1992): 469–72. https://doi.org/10.1016/0014-2999(92)90491-l.
Martin D, Swartzwelder HS. Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. Eur J Pharmacol. 1992 Sep 4;219(3):469–72.
Martin, D., and H. S. Swartzwelder. “Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1.” Eur J Pharmacol, vol. 219, no. 3, Sept. 1992, pp. 469–72. Pubmed, doi:10.1016/0014-2999(92)90491-l.
Martin D, Swartzwelder HS. Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. Eur J Pharmacol. 1992 Sep 4;219(3):469–472.
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
September 4, 1992
Volume
219
Issue
3
Start / End Page
469 / 472
Location
Netherlands
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Potassium
- Pharmacology & Pharmacy
- In Vitro Techniques
- Hippocampus
- Glutamic Acid
- Glutamates
- Female
- Ethanol