CD22 serves as a receptor for soluble IgM.

Journal Article (Journal Article)

CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

Full Text

Duke Authors

Cited Authors

  • Adachi, T; Harumiya, S; Takematsu, H; Kozutsumi, Y; Wabl, M; Fujimoto, M; Tedder, TF

Published Date

  • January 2012

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 241 - 247

PubMed ID

  • 21956693

Electronic International Standard Serial Number (EISSN)

  • 1521-4141

Digital Object Identifier (DOI)

  • 10.1002/eji.201141899


  • eng

Conference Location

  • Germany