Soft biodegradable polymersomes from caprolactone-derived polymers


Journal Article

Polymersomes have promise for advanced theranostic delivery. We report here the design and characterization of a series of block copolymers that assemble into soft, bioresorbable, and non-toxic vesicles. The polymers are based on poly(ethylene glycol)-poly(caprolactone), but the caprolactone (CL) is copolymerized with a second monomer, 1,4,8-trioxaspiro-[4,6]-9-undecanone (TOSUO). Because TOSUO polymers have no crystalline character, copolymerizing TOSUO with CL should reduce the crystallinity of the polymersomes. After synthesizing polymers with different ratios of CL to TOSUO, we found that all copolymers assemble into both micron and nano-metric vesicles. Increasing the TOSUO content of the copolymer reduces the polymer crystalline melting temperature and the area expansion modulus of vesicle membranes. Membranes with partial crystalline structure exhibit hysteresis in the tension versus strain curve during aspiration. Vesicles are not cytotoxic and exhibit first-order release of encapsulated gemcitabine. These materials are promising for the development of deformable, biodegradable polymersomes for biomedical applications. © 2012 The Royal Society of Chemistry.

Full Text

Duke Authors

Cited Authors

  • Katz, JS; Eisenbrown, KA; Johnston, ED; Kamat, NP; Rawson, J; Therien, MJ; Burdick, JA; Hammer, DA

Published Date

  • November 14, 2012

Published In

Volume / Issue

  • 8 / 42

Start / End Page

  • 10853 - 10862

Electronic International Standard Serial Number (EISSN)

  • 1744-6848

International Standard Serial Number (ISSN)

  • 1744-683X

Digital Object Identifier (DOI)

  • 10.1039/c2sm26275d

Citation Source

  • Scopus