Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface.


Journal Article

A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.

Full Text

Duke Authors

Cited Authors

  • Ye, S; Discher, BM; Strzalka, J; Xu, T; Wu, SP; Noy, D; Kuzmenko, I; Gog, T; Therien, MJ; Dutton, PL; Blasie, JK

Published Date

  • September 2005

Published In

Volume / Issue

  • 5 / 9

Start / End Page

  • 1658 - 1667

PubMed ID

  • 16159202

Pubmed Central ID

  • 16159202

Electronic International Standard Serial Number (EISSN)

  • 1530-6992

International Standard Serial Number (ISSN)

  • 1530-6984

Digital Object Identifier (DOI)

  • 10.1021/nl050542k


  • eng