Assembling the pieces.


Journal Article

Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.

Full Text

Cited Authors

  • Thiele, DJ; Gitlin, JD

Published Date

  • March 2008

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 145 - 147

PubMed ID

  • 18277968

Pubmed Central ID

  • 18277968

Electronic International Standard Serial Number (EISSN)

  • 1552-4469

Digital Object Identifier (DOI)

  • 10.1038/nchembio0308-145


  • eng

Conference Location

  • United States