Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.


Journal Article

From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion. Activation depends on the same type of MRE motifs in the upstream region of the Ctr1B gene as are normally required for metal induction. Thus, a single transcription factor, MTF-1, plays a direct role in both copper detoxification and acquisition by inducing the expression of metallothioneins and of a copper importer, respectively.

Full Text

Duke Authors

Cited Authors

  • Selvaraj, A; Balamurugan, K; Yepiskoposyan, H; Zhou, H; Egli, D; Georgiev, O; Thiele, DJ; Schaffner, W

Published Date

  • April 15, 2005

Published In

Volume / Issue

  • 19 / 8

Start / End Page

  • 891 - 896

PubMed ID

  • 15833915

Pubmed Central ID

  • 15833915

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1301805


  • eng

Conference Location

  • United States