Yeast metallothionein gene expression in response to metals and oxidative stress.


Journal Article (Review)

Metals and oxygen are chemically linked in biological systems. Metals and oxygen play important roles in enzymatic reactions, metabolism, and signal transduction; however, metals and oxygen react to form highly toxic oxygen-derived free radical species. In this review we focus on the use of yeast cells, as unicellular eukaryotic model systems, to conduct studies aimed at understanding fundamental mechanisms for the sensation and protective responses to toxic metals and oxygen-derived radicals via the activation of yeast metallothionein gene expression.

Full Text

Duke Authors

Cited Authors

  • Liu, XD; Thiele, DJ

Published Date

  • March 1997

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 289 - 299

PubMed ID

  • 9073572

Pubmed Central ID

  • 9073572

International Standard Serial Number (ISSN)

  • 1046-2023

Digital Object Identifier (DOI)

  • 10.1006/meth.1996.0423


  • eng

Conference Location

  • United States