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Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.

Publication ,  Journal Article
de Bono, M; Tobin, DM; Davis, MW; Avery, L; Bargmann, CI
Published in: Nature
October 31, 2002

Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 31, 2002

Volume

419

Issue

6910

Start / End Page

899 / 903

Location

England

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • Suppression, Genetic
  • Stress, Physiological
  • Social Behavior
  • Receptors, Odorant
  • Receptors, Neuropeptide Y
  • Pain
  • Nociceptors
  • Neurons
 

Citation

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de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002). Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature, 419(6910), 899–903. https://doi.org/10.1038/nature01169
Bono, Mario de, David M. Tobin, M Wayne Davis, Leon Avery, and Cornelia I. Bargmann. “Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.Nature 419, no. 6910 (October 31, 2002): 899–903. https://doi.org/10.1038/nature01169.
de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 2002 Oct 31;419(6910):899–903.
de Bono, Mario, et al. “Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.Nature, vol. 419, no. 6910, Oct. 2002, pp. 899–903. Pubmed, doi:10.1038/nature01169.
de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 2002 Oct 31;419(6910):899–903.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 31, 2002

Volume

419

Issue

6910

Start / End Page

899 / 903

Location

England

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • Suppression, Genetic
  • Stress, Physiological
  • Social Behavior
  • Receptors, Odorant
  • Receptors, Neuropeptide Y
  • Pain
  • Nociceptors
  • Neurons