Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.

Published

Journal Article

C. elegans OSM-9 is a TRPV channel protein involved in sensory transduction and adaptation. Here, we show that distinct sensory functions arise from different combinations of OSM-9 and related OCR TRPV proteins. Both OSM-9 and OCR-2 are essential for several forms of sensory transduction, including olfaction, osmosensation, mechanosensation, and chemosensation. In neurons that express both OSM-9 and OCR-2, tagged OCR-2 and OSM-9 proteins reside in sensory cilia and promote each other's localization to cilia. In neurons that express only OSM-9, tagged OSM-9 protein resides in the cell body and acts in sensory adaptation rather than sensory transduction. Thus, alternative combinations of TRPV proteins may direct different functions in distinct subcellular locations. Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior.

Full Text

Duke Authors

Cited Authors

  • Tobin, DM; Madsen, DM; Kahn-Kirby, A; Peckol, EL; Moulder, G; Barstead, R; Maricq, AV; Bargmann, CI

Published Date

  • July 18, 2002

Published In

Volume / Issue

  • 35 / 2

Start / End Page

  • 307 - 318

PubMed ID

  • 12160748

Pubmed Central ID

  • 12160748

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(02)00757-2

Language

  • eng

Conference Location

  • United States