Preparation and use of serum-based material as control and calibrator in evaluating ion-selective electrodes for calcium.

Journal Article (Journal Article)

We analyzed 93 sera and 81 whole-blood samples, plus several aqueous materials and one serum-based material as controls, with two analyzers for ionized calcium (Radiometer ICA 1 and AVL 980). On 16 days, comparisons of results for patients' samples were good, with nearly all between-instrument differences (delta Ca2+) of samples being within 0.04 mmol/L. On 12 days, comparisons were mediocre, with the delta Ca2+ of samples usually 0.04 to 0.10 mmol/L. The control material that most consistently indicated the direction and magnitude of the delta Ca2+ of patients' samples was the serum-based control. Adjustment of results for samples from patients, based on the delta Ca2+ of the serum control on the same day, substantially improved comparisons between instruments. Our findings suggest that the use of a serum-based calibrator provides the most valid comparison between different calcium-ion analyzers and reliably indicates when electrode replacement is needed.

Full Text

Duke Authors

Cited Authors

  • Toffaletti, J; Lee, KM

Published Date

  • August 1985

Published In

Volume / Issue

  • 31 / 8

Start / End Page

  • 1349 - 1352

PubMed ID

  • 4017239

International Standard Serial Number (ISSN)

  • 0009-9147


  • eng

Conference Location

  • England