Mitochondrial DNA alterations in thyroid cancer.

Published

Journal Article

BACKGROUND: Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding D-loop of the mitochondrial genome was identified and described as a mutational hotspot. The objective of the present study was to examine a series of thyroid cancers for genetic alterations in this region. METHODS: Seventy-two (72) thyroid cancers were examined for alterations in D310 using PCR-based methods. The primary tumors tested included 35 papillary carcinomas, 18 medullary carcinomas, 9 anaplastic carcinomas, 9 follicular carcinomas, and 1 insular carcinoma. RESULTS: Alterations in D310 were observed in 2/35 papillary carcinomas (5.7%), 1/18 medullary carcinomas (5.6%), 1/9 anaplastic carcinomas (11.1%), and 1/9 follicular carcinomas (11.1%). Overall, the rate of alterations was 5/72 (6.9%). CONCLUSIONS: Mutations in the D310 region of the D-loop of mitochondrial DNA are found in thyroid tumors of varying histologic types and grades. This mutation rate is lower than the reported rate of alteration in tumors of epithelial origin, and shows no relationship to histologic grade.

Full Text

Duke Authors

Cited Authors

  • Tong, BC; Ha, PK; Dhir, K; Xing, M; Westra, WH; Sidransky, D; Califano, JA

Published Date

  • March 2003

Published In

Volume / Issue

  • 82 / 3

Start / End Page

  • 170 - 173

PubMed ID

  • 12619060

Pubmed Central ID

  • 12619060

International Standard Serial Number (ISSN)

  • 0022-4790

Digital Object Identifier (DOI)

  • 10.1002/jso.10202

Language

  • eng

Conference Location

  • United States