Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.

Journal Article (Journal Article)

A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven subjects, one randomly selected breast was imaged prone-pendant using the dedicated, compact breast SPECT-CT system underneath the shielded patient support. Iteratively reconstructed and attenuation and/or scatter corrected images were coregistered; CT images were segmented into glandular and fatty tissue by three different methods; the average concentration of Sestamibi was determined from the SPECT data using the CT-based segmentation and previously established quantification techniques. Very minor differences between the segmentation methods were observed, and the results indicate an average image-based in vivo Sestamibi concentration of 0.10 ± 0.16 μCi/mL with no preferential uptake by glandular or fatty tissues.

Full Text

Duke Authors

Cited Authors

  • Mann, SD; Perez, KL; McCracken, EKE; Shah, JP; Wong, TZ; Tornai, MP

Published Date

  • 2012

Published In

Volume / Issue

  • 2012 /

Start / End Page

  • 146943 -

PubMed ID

  • 22956950

Pubmed Central ID

  • PMC3431100

Electronic International Standard Serial Number (EISSN)

  • 1687-8469

Digital Object Identifier (DOI)

  • 10.1155/2012/146943


  • eng

Conference Location

  • Egypt