Intracardiac echocardiography measurement of dynamic myocardial stiffness with shear wave velocimetry.

Journal Article (Journal Article)

Acoustic radiation force (ARF)-based methods have been demonstrated to be a viable tool for noninvasively estimating tissue elastic properties, and shear wave velocimetry has been used to measure quantitatively the stiffening and relaxation of myocardial tissue in open-chest experiments. Dynamic stiffness metrics may prove to be indicators for certain cardiac diseases, but a clinically viable means of remotely generating and tracking transverse wave propagation in myocardium is needed. Intracardiac echocardiography (ICE) catheter-tip transducers are demonstrated here as a viable tool for making this measurement. ICE probes achieve favorable proximity to the myocardium, enabling the use of shear wave velocimetry from within the right ventricle throughout the cardiac cycle. This article describes the techniques used to overcome the challenges of using a small probe to perform ARF-driven shear-wave velocimetry and presents in vivo porcine data showing the effectiveness of this method in the interventricular septum.

Full Text

Duke Authors

Cited Authors

  • Hollender, PJ; Wolf, PD; Goswami, R; Trahey, GE

Published Date

  • July 2012

Published In

Volume / Issue

  • 38 / 7

Start / End Page

  • 1271 - 1283

PubMed ID

  • 22579544

Pubmed Central ID

  • PMC3371183

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

International Standard Serial Number (ISSN)

  • 0301-5629

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2012.02.028


  • eng