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The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics

Publication ,  Journal Article
Doherty, JR; Dumont, DM; Trahey, GE
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
June 8, 2011

The progression of atherosclerotic disease, caused by the formation of plaques within arteries, is a complex process believed to be a function of the localized mechanical properties and hemodynamic loading associated with the arterial wall. It is hypothesized that measurements of vascular stiffness and wall-shear rate (WSR) may provide important information regarding vascular remodeling, endothelial function, and the growth of soft-lipid filled plaques that could help a clinician better diagnose a patient's risk of clinical events such as stroke. To that end, the approach taken in this work was to combine conventional B-mode, Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI), and spectral Doppler techniques into a single imaging system capable of simultaneously measuring the tissue displacements and WSR throughout the cardiac cycle and over several heartbeats. Implemented on a conventional scanner, the carotid arteries of human subjects were scanned to demonstrate the initial in vivo feasibility of the method. Two non-invasive ultrasound based imaging methods, SAD-SWEI and SAD-Gated Imaging, were developed that measure ARF-induced on-axis tissue displacements, off-axis transverse wave velocities, and WSR throughout the cardiac cycle. Human carotid artery scans were performed in vivo on 5 healthy subjects. Statistical differences were observed in both on-axis proximal wall displacements and transverse wave velocities during diastole compared to systole. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

June 8, 2011

Volume

7968
 

Citation

APA
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ICMJE
MLA
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Doherty, J. R., Dumont, D. M., & Trahey, G. E. (2011). The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7968. https://doi.org/10.1117/12.877606
Doherty, J. R., D. M. Dumont, and G. E. Trahey. “The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7968 (June 8, 2011). https://doi.org/10.1117/12.877606.
Doherty JR, Dumont DM, Trahey GE. The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2011 Jun 8;7968.
Doherty, J. R., et al. “The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7968, June 2011. Scopus, doi:10.1117/12.877606.
Doherty JR, Dumont DM, Trahey GE. The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2011 Jun 8;7968.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

June 8, 2011

Volume

7968