MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.


Journal Article

Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the NF1 patients. General linear models analysis of covariance revealed significantly larger brain volumes in NF1 children than in controls, particularly in white matter, and particularly in girls. JLO and DTVMI performance were positively related to right-hemisphere gray-matter volume. The results implicate a failure of growth control in NF1, leading to aberrant neurodevelopment. Our findings also suggest a basis for refined understanding of learning disabilities, which are a prominent feature of NF1.

Full Text

Duke Authors

Cited Authors

  • Said, SM; Yeh, TL; Greenwood, RS; Whitt, JK; Tupler, LA; Krishnan, KR

Published Date

  • August 12, 1996

Published In

Volume / Issue

  • 7 / 12

Start / End Page

  • 1941 - 1944

PubMed ID

  • 8905698

Pubmed Central ID

  • 8905698

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199608120-00015


  • eng

Conference Location

  • England