Women's interest in taking tamoxifen and raloxifene for breast cancer prevention: response to a tailored decision aid.

Journal Article (Journal Article)

Although tamoxifen can prevent primary breast cancer, few women use it as a preventive measure. A second option, raloxifene, has recently been approved. The objective of the study was to determine women's interest in tamoxifen and raloxifene after reading a decision aid (DA) describing the risks and benefits of each medication. Women with 5-year risk of breast cancer ≥ 1.66 from two large health maintenance organizations were randomized to receive a DA versus usual care. After reading an on-line DA that discussed the risks and benefits of tamoxifen and raloxifene, women completed measures of risk perception, decisional conflict, behavioral intentions, and actual behavior related to tamoxifen and raloxifene. 3 months following the intervention, 8.1% of participants had looked for additional information about breast cancer prevention drugs, and 1.8% had talked to their doctor about tamoxifen and/or raloxifene. The majority, 54.7%, had decided to not take either drug, 0.5% had started raloxifene, and none had started tamoxifen. Participants were not particularly worried about taking tamoxifen or raloxifene and did not perceive significant benefits from taking these drugs. Over 50% did not perceive a change in their risk of getting breast cancer if they took tamoxifen or raloxifene. After reading a DA about tamoxifen and raloxifene, few women were interested in taking either breast cancer prevention drug.

Full Text

Duke Authors

Cited Authors

  • Fagerlin, A; Dillard, AJ; Smith, DM; Zikmund-Fisher, BJ; Pitsch, R; McClure, JB; Greene, S; Alford, SH; Nair, V; Hayes, DF; Wiese, C; Ubel, PA

Published Date

  • June 2011

Published In

Volume / Issue

  • 127 / 3

Start / End Page

  • 681 - 688

PubMed ID

  • 21442198

Pubmed Central ID

  • PMC3742062

Electronic International Standard Serial Number (EISSN)

  • 1573-7217

International Standard Serial Number (ISSN)

  • 0167-6806

Digital Object Identifier (DOI)

  • 10.1007/s10549-011-1450-1


  • eng