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The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil.

Publication ,  Journal Article
Chen, LE; Seaber, AV; Otto-Hagen, P; Urbaniak, J
Published in: J Reconstr Microsurg
January 1993

The vascular endothelium plays an important role in the regulation of vascular tone, by producing both vasodilating and vasoconstricting mediators. Using intravital videomicroscopy, this study examined the in vivo responses of the rat cremaster muscle microcirculation to topical application of endothelin-1 (ET-1), as well as the effect of verapamil pretreatment on these responses. ET-1 produced a potent and persistent vasoconstriction in arteries and veins which lasted for 150 min. The contractile response to ET-1 was significantly more prolonged in arterioles (11 to 30 microns) than in small arteries (40 to 70 microns). Pretreatment of the muscle with verapamil did not inhibit the initial vasoconstrictive action of ET-1, but produced a significant (p < 0.0001) reduction in the recovery time required for vessel relaxation in both small arteries and arterioles. The results suggest that Ca2+ channels contribute to the prolonged vasoconstriction induced in microvessels by ET-1. Because this prolonged vasoconstriction may be responsible for the "no-reflow" phenomenon which occurs in microsurgical procedures, therapy with a calcium antagonist may be useful in attenuating its duration.

Duke Scholars

Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

January 1993

Volume

9

Issue

1

Start / End Page

49 / 54

Location

United States

Related Subject Headings

  • Verapamil
  • Time Factors
  • Surgery
  • Rats, Sprague-Dawley
  • Rats
  • Muscles
  • Microcirculation
  • Male
  • Endothelins
  • Drug Interactions
 

Citation

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ICMJE
MLA
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Chen, L. E., Seaber, A. V., Otto-Hagen, P., & Urbaniak, J. (1993). The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. J Reconstr Microsurg, 9(1), 49–54. https://doi.org/10.1055/s-2007-1006638
Chen, L. E., A. V. Seaber, P. Otto-Hagen, and J. Urbaniak. “The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil.J Reconstr Microsurg 9, no. 1 (January 1993): 49–54. https://doi.org/10.1055/s-2007-1006638.
Chen LE, Seaber AV, Otto-Hagen P, Urbaniak J. The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. J Reconstr Microsurg. 1993 Jan;9(1):49–54.
Chen, L. E., et al. “The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil.J Reconstr Microsurg, vol. 9, no. 1, Jan. 1993, pp. 49–54. Pubmed, doi:10.1055/s-2007-1006638.
Chen LE, Seaber AV, Otto-Hagen P, Urbaniak J. The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. J Reconstr Microsurg. 1993 Jan;9(1):49–54.
Journal cover image

Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

January 1993

Volume

9

Issue

1

Start / End Page

49 / 54

Location

United States

Related Subject Headings

  • Verapamil
  • Time Factors
  • Surgery
  • Rats, Sprague-Dawley
  • Rats
  • Muscles
  • Microcirculation
  • Male
  • Endothelins
  • Drug Interactions