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Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci.

Publication ,  Journal Article
Uyenoyama, MK; Waller, DM
Published in: Theoretical population biology
October 1991

We study the evolution of the rate of self-fertilization in response to deleterious mutations at multiple loci. Although partial selfing induces associations among loci even in the absence of linkage, associations among mutations at different loci are of a smaller order of magnitude than the mutation rate. Genotypes that carry homozygous lethal mutations in heterozygous form at i loci occur in frequencies of the order (Ti) mu i, in which T denotes the number of viability loci and mu the mutation rate. While associations between mutations at different loci remain small even under inbreeding, each viability locus develops an association with the modifier of the rate of self-fertilization that substantially affects the evolution of the breeding system. Positive associations between enhancers of selfing and haplotypes carrying multiple wild-type alleles and positive associations in heterozygosity between the modifier locus and the viability loci promote evolutionary increases in the rate of self-fertilization.

Duke Scholars

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

October 1991

Volume

40

Issue

2

Start / End Page

173 / 210

Related Subject Headings

  • Pollen
  • Mutation
  • Inbreeding
  • Homozygote
  • Genetic Linkage
  • Fertilization
  • Evolutionary Biology
  • Epistasis, Genetic
  • Biometry
  • 4901 Applied mathematics
 

Citation

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ICMJE
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Uyenoyama, M. K., & Waller, D. M. (1991). Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci. Theoretical Population Biology, 40(2), 173–210. https://doi.org/10.1016/0040-5809(91)90052-h
Uyenoyama, M. K., and D. M. Waller. “Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci.Theoretical Population Biology 40, no. 2 (October 1991): 173–210. https://doi.org/10.1016/0040-5809(91)90052-h.
Uyenoyama MK, Waller DM. Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci. Theoretical population biology. 1991 Oct;40(2):173–210.
Uyenoyama, M. K., and D. M. Waller. “Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci.Theoretical Population Biology, vol. 40, no. 2, Oct. 1991, pp. 173–210. Epmc, doi:10.1016/0040-5809(91)90052-h.
Uyenoyama MK, Waller DM. Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci. Theoretical population biology. 1991 Oct;40(2):173–210.
Journal cover image

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

October 1991

Volume

40

Issue

2

Start / End Page

173 / 210

Related Subject Headings

  • Pollen
  • Mutation
  • Inbreeding
  • Homozygote
  • Genetic Linkage
  • Fertilization
  • Evolutionary Biology
  • Epistasis, Genetic
  • Biometry
  • 4901 Applied mathematics