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Applications of 211AT and 223RA in targeted alpha-particle radiotherapy

Publication ,  Journal Article
Vaidyanathan, G; Zalutsky, MR
Published in: Current Radiopharmaceuticals
2011

Targeted radiotherapy using agents tagged with α-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used α-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted α-particle radiotherapy. © 2011 Bentham Science Publishers Ltd.

Duke Scholars

Published In

Current Radiopharmaceuticals

ISSN

1874-4710

Publication Date

2011

Volume

4

Issue

4

Start / End Page

283 / 294

Related Subject Headings

  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences
 

Citation

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Vaidyanathan, G., & Zalutsky, M. R. (2011). Applications of 211AT and 223RA in targeted alpha-particle radiotherapy. Current Radiopharmaceuticals, 4(4), 283–294.
Vaidyanathan, G., and M. R. Zalutsky. “Applications of 211AT and 223RA in targeted alpha-particle radiotherapy.” Current Radiopharmaceuticals 4, no. 4 (2011): 283–94.
Vaidyanathan G, Zalutsky MR. Applications of 211AT and 223RA in targeted alpha-particle radiotherapy. Current Radiopharmaceuticals. 2011;4(4):283–94.
Vaidyanathan, G., and M. R. Zalutsky. “Applications of 211AT and 223RA in targeted alpha-particle radiotherapy.” Current Radiopharmaceuticals, vol. 4, no. 4, 2011, pp. 283–94.
Vaidyanathan G, Zalutsky MR. Applications of 211AT and 223RA in targeted alpha-particle radiotherapy. Current Radiopharmaceuticals. 2011;4(4):283–294.
Journal cover image

Published In

Current Radiopharmaceuticals

ISSN

1874-4710

Publication Date

2011

Volume

4

Issue

4

Start / End Page

283 / 294

Related Subject Headings

  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences