Emerging roles for lipid droplets in immunity and host-pathogen interactions.

Published

Journal Article (Review)

Lipid droplets (LDs) are neutral lipid storage organelles ubiquitous to eukaryotic cells. It is increasingly recognized that LDs interact extensively with other organelles and that they perform functions beyond passive lipid storage and lipid homeostasis. One emerging function for LDs is the coordination of immune responses, as these organelles participate in the generation of prostaglandins and leukotrienes, which are important inflammation mediators. Similarly, LDs are also beginning to be recognized as playing a role in interferon responses and in antigen cross presentation. Not surprisingly, there is emerging evidence that many pathogens, including hepatitis C and Dengue viruses, Chlamydia, and Mycobacterium, target LDs during infection either for nutritional purposes or as part of an anti-immunity strategy. We here review recent findings that link LDs to the regulation and execution of immune responses in the context of host-pathogen interactions.

Full Text

Duke Authors

Cited Authors

  • Saka, HA; Valdivia, R

Published Date

  • 2012

Published In

Volume / Issue

  • 28 /

Start / End Page

  • 411 - 437

PubMed ID

  • 22578141

Pubmed Central ID

  • 22578141

Electronic International Standard Serial Number (EISSN)

  • 1530-8995

Digital Object Identifier (DOI)

  • 10.1146/annurev-cellbio-092910-153958

Language

  • eng

Conference Location

  • United States