Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

Published

Journal Article (Review)

The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial attachment site, which culminates in the engulfment of the bacterium by plasma membrane extensions. Numerous Salmonella and Shigella effectors promote this remodeling by activating Rho GTPases and tyrosine kinase signaling cascades and by directly manipulating actin dynamics. Recent studies indicate that similar host-cell alterations occur during Chlamydia invasion, but few effectors are known. The identification of additional Chlamydia effectors and the elucidation of their modes of function are critical steps towards an understanding of how this clinically important pathogen breaches epithelial surfaces and causes infection.

Full Text

Duke Authors

Cited Authors

  • Dunn, JD; Valdivia, RH

Published Date

  • August 2010

Published In

Volume / Issue

  • 5 / 8

Start / End Page

  • 1219 - 1232

PubMed ID

  • 20722600

Pubmed Central ID

  • 20722600

Electronic International Standard Serial Number (EISSN)

  • 1746-0921

Digital Object Identifier (DOI)

  • 10.2217/fmb.10.77

Language

  • eng

Conference Location

  • England