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Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

Publication ,  Journal Article
Dunn, JD; Valdivia, RH
Published in: Future Microbiol
August 2010

The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial attachment site, which culminates in the engulfment of the bacterium by plasma membrane extensions. Numerous Salmonella and Shigella effectors promote this remodeling by activating Rho GTPases and tyrosine kinase signaling cascades and by directly manipulating actin dynamics. Recent studies indicate that similar host-cell alterations occur during Chlamydia invasion, but few effectors are known. The identification of additional Chlamydia effectors and the elucidation of their modes of function are critical steps towards an understanding of how this clinically important pathogen breaches epithelial surfaces and causes infection.

Duke Scholars

Published In

Future Microbiol

DOI

EISSN

1746-0921

Publication Date

August 2010

Volume

5

Issue

8

Start / End Page

1219 / 1232

Location

England

Related Subject Headings

  • Virulence Factors
  • Shigella
  • Salmonella
  • Models, Biological
  • Microbiology
  • Humans
  • Epithelial Cells
  • Endocytosis
  • Cytoskeleton
  • Chlamydia trachomatis
 

Citation

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Dunn, J. D., & Valdivia, R. H. (2010). Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells. Future Microbiol, 5(8), 1219–1232. https://doi.org/10.2217/fmb.10.77
Dunn, Joe Dan, and Raphael H. Valdivia. “Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.Future Microbiol 5, no. 8 (August 2010): 1219–32. https://doi.org/10.2217/fmb.10.77.
Dunn, Joe Dan, and Raphael H. Valdivia. “Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.Future Microbiol, vol. 5, no. 8, Aug. 2010, pp. 1219–32. Pubmed, doi:10.2217/fmb.10.77.
Journal cover image

Published In

Future Microbiol

DOI

EISSN

1746-0921

Publication Date

August 2010

Volume

5

Issue

8

Start / End Page

1219 / 1232

Location

England

Related Subject Headings

  • Virulence Factors
  • Shigella
  • Salmonella
  • Models, Biological
  • Microbiology
  • Humans
  • Epithelial Cells
  • Endocytosis
  • Cytoskeleton
  • Chlamydia trachomatis