Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments.


Journal Article (Review)

Many intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids. Although intracellular lifestyles offer protection from humoral immune responses, vacuole-bound pathogens nevertheless face powerful intracellular innate immune surveillance pathways that can trigger fusion with lysosomes, autophagy, and host cell death. Strategies used by vacuole-bound pathogens to invade and establish a replicative vacuole are well described, but how the integrity and stability of these parasitic vacuoles are maintained is poorly understood. Here, we identify potential mechanisms of pathogenic vacuole maintenance and the consequences of vacuole disruption by highlighting select bacterial and protozoan parasites.

Full Text

Duke Authors

Cited Authors

  • Kumar, Y; Valdivia, RH

Published Date

  • June 18, 2009

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 593 - 601

PubMed ID

  • 19527886

Pubmed Central ID

  • 19527886

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2009.05.014


  • eng

Conference Location

  • United States