Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments.
Many intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids. Although intracellular lifestyles offer protection from humoral immune responses, vacuole-bound pathogens nevertheless face powerful intracellular innate immune surveillance pathways that can trigger fusion with lysosomes, autophagy, and host cell death. Strategies used by vacuole-bound pathogens to invade and establish a replicative vacuole are well described, but how the integrity and stability of these parasitic vacuoles are maintained is poorly understood. Here, we identify potential mechanisms of pathogenic vacuole maintenance and the consequences of vacuole disruption by highlighting select bacterial and protozoan parasites.
Duke Scholars
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Related Subject Headings
- Vacuoles
- Models, Biological
- Immunology
- Host-Pathogen Interactions
- Eukaryota
- Bacterial Physiological Phenomena
- Animals
- 3207 Medical microbiology
- 3107 Microbiology
- 3101 Biochemistry and cell biology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Vacuoles
- Models, Biological
- Immunology
- Host-Pathogen Interactions
- Eukaryota
- Bacterial Physiological Phenomena
- Animals
- 3207 Medical microbiology
- 3107 Microbiology
- 3101 Biochemistry and cell biology