Chlamydia effector proteins and new insights into chlamydial cellular microbiology.

Journal Article (Journal Article;Review)

Chlamydia and Chlamydophila sp. are highly related obligate intracellular bacterial pathogens that cause sexually transmitted diseases, ocular infections and atypical pneumonias. Relatively little is known about the molecular mechanisms by which Chlamydiae manipulate the mammalian host because they are intractable to genetic manipulation. Studies with heterologous expression systems have revealed a large set of chlamydial proteins that are potentially translocated into the host cytoplasm ('effector' proteins). As new cell biological observations are made and the function of effector proteins begin to be elucidated, a clearer picture of the extent to which Chlamydiae manipulate mammalian cellular processes is beginning to emerge, including the cell cycle, innate immunity, and lipid and membrane transport.

Full Text

Duke Authors

Cited Authors

  • Valdivia, RH

Published Date

  • February 2008

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 53 - 59

PubMed ID

  • 18299248

International Standard Serial Number (ISSN)

  • 1369-5274

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2008.01.003


  • eng

Conference Location

  • England