The response of depressed inpatients to isocarboxazid.

Journal Article (Clinical Trial;Journal Article)

Fifty-six inpatients with unipolar depression completed treatment with isocarboxazid. In comparing the differences between responders and nonresponders, it was found that psychomotor retardation, pathological guilt, daily persistence of unremitting symptoms, phobic anxiety, dexamethasone suppression test nonsuppression, and neuroticism were significantly more common among nonresponders. Reactivity of mood, blaming others, and extraversion were more common in responders. Total endogenous depression scores on the Newcastle 1, Newcastle 2, and Michigan scales were also significantly higher in nonresponders. Attained platelet monoamine oxidase inhibition was similar in both groups.

Full Text

Duke Authors

Cited Authors

  • Davidson, J; Lipper, S; Pelton, S; Miller, RD; Hammett, EB; Mahorney, S; Varia, IM

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 100 - 107

PubMed ID

  • 3372704

International Standard Serial Number (ISSN)

  • 0271-0749


  • eng

Conference Location

  • United States