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A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.

Publication ,  Journal Article
Rea, SL; Wu, D; Cypser, JR; Vaupel, JW; Johnson, TE
Published in: Nature genetics
August 2005

When both genotype and environment are held constant, 'chance' variation in the lifespan of individuals in a population is still quite large. Using isogenic populations of the nematode Caenorhabditis elegans, we show that, on the first day of adult life, chance variation in the level of induction of a green fluorescent protein (GFP) reporter coupled to a promoter from the gene hsp-16.2 predicts as much as a fourfold variation in subsequent survival. The same reporter is also a predictor of ability to withstand a subsequent lethal thermal stress. The level of induction of GFP is not heritable, and GFP expression levels in other reporter constructs are not associated with differences in longevity. HSP-16.2 itself is probably not responsible for the observed differences in survival but instead probably reflects a hidden, heterogeneous, but now quantifiable, physiological state that dictates the ability of an organism to deal with the rigors of living.

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Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

August 2005

Volume

37

Issue

8

Start / End Page

894 / 898

Related Subject Headings

  • Stress, Physiological
  • Promoter Regions, Genetic
  • Longevity
  • Heat-Shock Proteins
  • Green Fluorescent Proteins
  • Genes, Reporter
  • Developmental Biology
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals
 

Citation

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Rea, S. L., Wu, D., Cypser, J. R., Vaupel, J. W., & Johnson, T. E. (2005). A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nature Genetics, 37(8), 894–898. https://doi.org/10.1038/ng1608
Rea, Shane L., Deqing Wu, James R. Cypser, James W. Vaupel, and Thomas E. Johnson. “A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.Nature Genetics 37, no. 8 (August 2005): 894–98. https://doi.org/10.1038/ng1608.
Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nature genetics. 2005 Aug;37(8):894–8.
Rea, Shane L., et al. “A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.Nature Genetics, vol. 37, no. 8, Aug. 2005, pp. 894–98. Epmc, doi:10.1038/ng1608.
Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nature genetics. 2005 Aug;37(8):894–898.

Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

August 2005

Volume

37

Issue

8

Start / End Page

894 / 898

Related Subject Headings

  • Stress, Physiological
  • Promoter Regions, Genetic
  • Longevity
  • Heat-Shock Proteins
  • Green Fluorescent Proteins
  • Genes, Reporter
  • Developmental Biology
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals