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An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

Publication ,  Journal Article
Bonafè, M; Barbi, C; Olivieri, F; Yashin, A; Andreev, KF; Vaupel, JW; De Benedictis, G; Rose, G; Carrieri, G; Jazwinski, SM; Franceschi, C
Published in: Gene
March 2002

The human HRAS1 belongs to an evolutionarily-conserved family of genes which enrolls among its members the yeast RAS2, a gene which regulates stress response and longevity in the Saccharomyces cerevisiae. In this paper we report that the frequency of the a3 allele of HRAS1 3'variable number tandem repeat (HRAS1 3'VNTR) decreases in centenarians in respect to young people, and we estimate that during aging a3 carriers have a relative mortality risk of 1.126 (95% CI=1.044-1.213). We propose that the germ-line variability at the HRAS1 locus impacts on the individual's capacity to reach the extreme limits of human life-span. Furthermore, we provide suggestive evidence that a3 HRAS1 3'VNTR allele and inherited variants of the mitochondrial genome (mtDNA haplogroups) do not affect independently human longevity, thus recalling the nucleus-mitochondrion interaction which regulates stress response and life-span in the yeast.

Duke Scholars

Published In

Gene

DOI

EISSN

1879-0038

ISSN

0378-1119

Publication Date

March 2002

Volume

286

Issue

1

Start / End Page

121 / 126

Related Subject Headings

  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Longevity
  • Italy
  • Humans
  • Haplotypes
  • Genotype
  • Genes, ras
  • Gene Frequency
 

Citation

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Bonafè, M., Barbi, C., Olivieri, F., Yashin, A., Andreev, K. F., Vaupel, J. W., … Franceschi, C. (2002). An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. Gene, 286(1), 121–126. https://doi.org/10.1016/s0378-1119(01)00812-5
Bonafè, Massimiliano, Cristiana Barbi, Fabiola Olivieri, Anatoli Yashin, Kirill F. Andreev, James W. Vaupel, Giovanna De Benedictis, et al. “An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.Gene 286, no. 1 (March 2002): 121–26. https://doi.org/10.1016/s0378-1119(01)00812-5.
Bonafè M, Barbi C, Olivieri F, Yashin A, Andreev KF, Vaupel JW, et al. An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. Gene. 2002 Mar;286(1):121–6.
Bonafè, Massimiliano, et al. “An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.Gene, vol. 286, no. 1, Mar. 2002, pp. 121–26. Epmc, doi:10.1016/s0378-1119(01)00812-5.
Bonafè M, Barbi C, Olivieri F, Yashin A, Andreev KF, Vaupel JW, De Benedictis G, Rose G, Carrieri G, Jazwinski SM, Franceschi C. An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. Gene. 2002 Mar;286(1):121–126.
Journal cover image

Published In

Gene

DOI

EISSN

1879-0038

ISSN

0378-1119

Publication Date

March 2002

Volume

286

Issue

1

Start / End Page

121 / 126

Related Subject Headings

  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Longevity
  • Italy
  • Humans
  • Haplotypes
  • Genotype
  • Genes, ras
  • Gene Frequency