Cardiovascular mortality in twins and the fetal origins hypothesis.


Journal Article

The intrauterine growth patterns for twins are characterized by normal development during the first two trimesters and reduced growth during the third trimester. According to the fetal origins hypothesis this growth pattern is associated with risk factors for cardiovascular morbidity and mortality. We studied cause-specific mortality of 19,986 Danish twin individuals from the birth cohorts 1870-1930 followed from 1952 through 1993. Despite the large sample size and follow-up period we were not able to detect any difference between twins and the general population with regard to all-cause mortality or cardiovascular mortality. Hence, the intrauterine growth retardation experienced by twins does not result in any "fetal programming" of cardiovascular diseases. There is still an important role for twins (and other sibs) to play in the testing of the fetal origins hypothesis, namely in studies of intra-pair differences, which can assess the role of genetic confounding in the association between fetal growth and later health outcome.

Full Text

Duke Authors

Cited Authors

  • Christensen, K; Wienke, A; Skytthe, A; Holm, NV; Vaupel, JW; Yashin, AI

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 344 - 349

PubMed ID

  • 11869487

Pubmed Central ID

  • 11869487

International Standard Serial Number (ISSN)

  • 1369-0523

Digital Object Identifier (DOI)

  • 10.1375/1369052012506


  • eng