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Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables.

Publication ,  Journal Article
Yashin, AI; Manton, KG; Vaupel, JW
Published in: Theoretical population biology
April 1985

Various multivariate stochastic process models have been developed to represent human physiological aging and mortality. These efforts are extended by considering the effects of observed and unobserved state variables on the age trajectory of physiological parameters. This is done by deriving the Kolmogorov-Fokker-Planck equations describing the distribution of the unobserved state variables conditional on the history of the observed state variables. Given some assumptions, it is proved that the distribution is Gaussian. Strategies for estimating the parameters of the distribution are suggested based on an extension of the theory of Kalman filters to include systematic mortality selection. Various empirical applications of the model to studies of human aging and mortality as well as to other types of "failure" processes in heterogeneous populations are discussed.

Duke Scholars

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

April 1985

Volume

27

Issue

2

Start / End Page

154 / 175

Related Subject Headings

  • Stochastic Processes
  • Risk
  • Mortality
  • Models, Biological
  • Humans
  • Evolutionary Biology
  • Analysis of Variance
  • Aging
  • 4901 Applied mathematics
  • 3104 Evolutionary biology
 

Citation

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Yashin, A. I., Manton, K. G., & Vaupel, J. W. (1985). Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables. Theoretical Population Biology, 27(2), 154–175. https://doi.org/10.1016/0040-5809(85)90008-5
Yashin, A. I., K. G. Manton, and J. W. Vaupel. “Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables.Theoretical Population Biology 27, no. 2 (April 1985): 154–75. https://doi.org/10.1016/0040-5809(85)90008-5.
Yashin AI, Manton KG, Vaupel JW. Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables. Theoretical population biology. 1985 Apr;27(2):154–75.
Yashin, A. I., et al. “Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables.Theoretical Population Biology, vol. 27, no. 2, Apr. 1985, pp. 154–75. Epmc, doi:10.1016/0040-5809(85)90008-5.
Yashin AI, Manton KG, Vaupel JW. Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables. Theoretical population biology. 1985 Apr;27(2):154–175.
Journal cover image

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

April 1985

Volume

27

Issue

2

Start / End Page

154 / 175

Related Subject Headings

  • Stochastic Processes
  • Risk
  • Mortality
  • Models, Biological
  • Humans
  • Evolutionary Biology
  • Analysis of Variance
  • Aging
  • 4901 Applied mathematics
  • 3104 Evolutionary biology