Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy.

Published

Journal Article

The goal of this experiment was to identify the presence of genetic variants in the adenosine receptor genes and assess their relationship to infarct size in a population of patients with ischemic cardiomyopathy. Adenosine receptors play an important role in protecting the heart during ischemia and in mediating the effects of ischemic preconditioning. We sequenced DNA samples from 273 individuals with ischemic cardiomyopathy and from 203 normal controls to identify the presence of genetic variants in the adenosine receptor genes. Subsequently, we analyzed the relationship between the identified genetic variants and infarct size, left ventricular size, and left ventricular function. Three variants in the 3'-untranslated region of the A(1)-adenosine gene (nt 1689 C/A, nt 2206 Tdel, nt 2683del36) and an informative polymorphism in the coding region of the A3-adenosine gene (nt 1509 A/C I248L) were associated with changes in infarct size. These results suggest that genetic variants in the adenosine receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.

Full Text

Cited Authors

  • Tang, Z; Diamond, MA; Chen, J-M; Holly, TA; Bonow, RO; Dasgupta, A; Hyslop, T; Purzycki, A; Wagner, J; McNamara, DM; Kukulski, T; Wos, S; Velazquez, EJ; Ardlie, K; Feldman, AM

Published Date

  • October 2007

Published In

Volume / Issue

  • 82 / 4

Start / End Page

  • 435 - 440

PubMed ID

  • 17728764

Pubmed Central ID

  • 17728764

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1038/sj.clpt.6100331

Language

  • eng

Conference Location

  • United States