The scope of receptor editing and its association with autoimmunity.

Published

Journal Article (Review)

Random assembly of antibody variable (V), diversity (D) and joining (J) gene segments creates a vast repertoire of antigen receptors, including autoreactive ones. Three ways that are known to reduce autoreactivity in the B-cell compartment include clonal deletion, functional inactivation and receptor editing, a mechanism involving a change in antigen receptor specificity through continued V(D)J recombination. New data suggest that editing can efficiently eliminate autoreactivity, yet, in an autoimmune context, secondary antibody gene rearrangements might also contribute to autoimmunity.

Full Text

Duke Authors

Cited Authors

  • Verkoczy, LK; Mårtensson, AS; Nemazee, D

Published Date

  • December 2004

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 808 - 814

PubMed ID

  • 15511677

Pubmed Central ID

  • 15511677

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2004.09.017

Language

  • eng

Conference Location

  • England