Immunohistochemical localization of bombesin-like peptides in the digestive tract of the bowfin, Amia calva


Journal Article

1. The distribution of bombesin-like immunoreactivity was determined in the gastrointestinal tract of the primitive holostean fish, the bowfin (Amia calva) using immunocytochemistry. 2. Immunostaining using two different antisera raised against frog skin bombesin revealed a population of apparent endocrine cells containing bombesin-like immunoreactivity in the epithelium of the antral mucosa in the stomach. 3. No bombesin-containing endocrine cells were present in any other segment of the gut. Bombesinergic nerves were not observed anywhere in the bowfin gastrointestinal tract. 4. The antral bombesin endocrine cells were of the open type and were distributed diffusely from the base to the tips of antral glands, with some tendency to cluster near the base of the glands. 5. These results suggest that a bombesin-like peptide may play an endocrine role in control of gastric functions such as regulation of acid secretion and gastric motility. These results support the hypothesis that bombesin serves a role in bony fish analogous to the role of antral cholecystokinin in amphibia and antral gastrin in amniotes. © 1990.

Full Text

Duke Authors

Cited Authors

  • Rajjo, IM; Vigna, SR; Crim, JW

Published Date

  • January 1, 1989

Published In

Volume / Issue

  • 94 / 2

Start / End Page

  • 405 - 409

International Standard Serial Number (ISSN)

  • 0306-4492

Digital Object Identifier (DOI)

  • 10.1016/0742-8413(89)90089-3

Citation Source

  • Scopus