Casein kinase 1: Complexity in the family.

Journal Article (Journal Article;Review)

The CK1 family of serine/threonine kinases regulates diverse cellular processes, through binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates primed by prior phosphorylation, and works closely with other kinases in the Wnt pathway. CK1 is itself regulated by posttranslational modification, including autophosphorylation. We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms.

Full Text

Duke Authors

Cited Authors

  • Cheong, JK; Virshup, DM

Published Date

  • April 2011

Published In

Volume / Issue

  • 43 / 4

Start / End Page

  • 465 - 469

PubMed ID

  • 21145983

Electronic International Standard Serial Number (EISSN)

  • 1878-5875

Digital Object Identifier (DOI)

  • 10.1016/j.biocel.2010.12.004


  • eng

Conference Location

  • Netherlands