Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 knockout


Journal Article

A comparative study of growth cone morphology in cultured embryonic neurons derived from wild type PS1(+/+) and knockout PS1(-/-) mice has been performed. Growth cones from wild type PS1(+/+) mice were well spread and usually formed radially continuous and regular lamellar extensions, short filopodia. In contrast, most growth cones from knockout PS1(-/-) mice collapsed after 3-4 days in culture. Summarizing these data, we suggest that PS1 plays an important role in growth cone structure by stabilizing the integrity of the cytoskeleton. The growth cone collapse may be the main reason of abnormal neuronal migration and impaired synaptic function in PS1(-/-) mice. © 2008 Pleiades Publishing, Ltd.

Full Text

Duke Authors

Cited Authors

  • Shwartsman, AL; Sarantseva, SV; Solovyov, KV; Runova, OL; Talalaeva, EI; Vitek, MP

Published Date

  • December 1, 2008

Published In

Volume / Issue

  • 53 / 6

Start / End Page

  • 550 - 554

Electronic International Standard Serial Number (EISSN)

  • 1555-6654

International Standard Serial Number (ISSN)

  • 0006-3509

Digital Object Identifier (DOI)

  • 10.1134/S0006350908060158

Citation Source

  • Scopus