[Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 gene knockout].


Journal Article

A comparative study of growth cone morphology in cultured embryonic neurons derived from wild type PS 1(+/+) and knockout PS 1(-/-) mice has been performed. Growth cones from wild type PS 1(+/+) mice were well spread and usually formed radially continuous and regular lamellar extensions with numerous filopodia. In contrast, most growth cones from knockout PS 1(-/-) mice exhibited small lamellar extensions, short filopodia, and pure adhesion. A significant amount of growth cones from knockout PS 1(-/-) mice collapsed after 3-4 days in culture. It was suggested that PS 1 plays an important role in growth cone structure by stabilizing the integrity of the cytoskeleton. The growth cone collapse may be the main reason for abnormal neuronal migration and impaired synaptic function in PS 1(-/-) mice.

Full Text

Duke Authors

Cited Authors

  • Shvartsman, AL; Sarantseva, SV; Solov'ev, KV; Runova, OL; Talalaeva, EI; Vitek, MP

Published Date

  • November 2008

Published In

Volume / Issue

  • 53 / 6

Start / End Page

  • 1008 - 1013

PubMed ID

  • 19137685

Pubmed Central ID

  • 19137685

International Standard Serial Number (ISSN)

  • 0006-3029


  • rus

Conference Location

  • Russia (Federation)