Presenilin 1 expression on the cell surface in motile polarized cells


Journal Article

Most cases of early-onset familial Alzheimer's disease are caused by mutations in the presenilin 1 gene. Nonetheless, the function of presenilin 1 are not yet completely understood. It was shown that endogenous presenilin 1, as well as the adhesion protein CD44, is concentrated on the surface of lamellipodia of polarized T cells (Jurkat cells) after adhesion to a collagen matrix. This phenomenon was not observed for another surface protein of T cells, T cell receptor, which is not involved in cell adhesion processes. In cultures of primary mouse cortical neurons, presenilin 1 was concentrated on the surface of the growth cone and at neurite contact sites. The concentration of presenilin 1 on the surface of structures that determine cell motility and intercellular contacts suggests that presenilin 1 plays an important role in cell adhesion in motile polarized cells. © Nauka/Interperiodica 2006.

Full Text

Duke Authors

Cited Authors

  • Schwartsman, AL; Sarantseva, SV; Tatishcheva, YA; Runova, OL; Talalaeva, EI; Vitek, MP

Published Date

  • October 1, 2006

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 740 - 743

Electronic International Standard Serial Number (EISSN)

  • 1555-6654

International Standard Serial Number (ISSN)

  • 0006-3509

Digital Object Identifier (DOI)

  • 10.1134/S0006350906050125

Citation Source

  • Scopus