A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.

Journal Article (Journal Article;Review)

Nitric oxide (nitrogen monoxide, NO) plays a veritable cornucopia of regulatory roles in normal physiology. In contrast, NO has also been implicated in the etiology and sequela of numerous neurodegenerative diseases that involve reactive oxygen species (ROS) and nitrogen oxide species (RNOS). In this setting, NO is often viewed solely as pathogenic; however, the chemistry of NO can also be a significant factor in lessening injury mediated by both ROS and RNOS. The relationship between NO and oxidation, nitrosation, and nitration reactions is summarized. The salient factors that determine whether NO promotes, abates, or interconnects these chemistries are emphasized. From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted.

Full Text

Duke Authors

Cited Authors

  • Espey, MG; Miranda, KM; Thomas, DD; Xavier, S; Citrin, D; Vitek, MP; Wink, DA

Published Date

  • May 2002

Published In

Volume / Issue

  • 962 /

Start / End Page

  • 195 - 206

PubMed ID

  • 12076975

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2002.tb04068.x


  • eng

Conference Location

  • United States