Scholars@Duke publication: Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.

Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.

Publication , Journal Article

Rada, P; Mark, GP; Vitek, MP; Mangano, RM; Blume, AJ; Beer, B; Hoebel, BG

Published in: Brain Res

June 7, 1991

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute response in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1 beta (7.5-50 micrograms/kg) decreased extracellular acetylcholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

Duke Scholars

Author Pedro Vicente Rada Rincon DKU Faculty

Author Michael P. Vitek Neurology, Behavioral Neurology

Published In

Brain Res

DOI

10.1016/0006-8993(91)91330-4

ISSN

0006-8993

Publication Date

June 7, 1991

Volume

550

Issue

Start / End Page

287 / 290

Location

Netherlands

Related Subject Headings

Recombinant Proteins
Rats, Inbred Strains
Rats
Neurology & Neurosurgery
Male
Kinetics
Interleukin-1
Hippocampus
Extracellular Space
Dialysis

Citation

APA

Chicago

ICMJE

MLA

NLM

Rada, P., Mark, G. P., Vitek, M. P., Mangano, R. M., Blume, A. J., Beer, B., & Hoebel, B. G. (1991). Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res, 550(2), 287–290. https://doi.org/10.1016/0006-8993(91)91330-4

Rada, P., G. P. Mark, M. P. Vitek, R. M. Mangano, A. J. Blume, B. Beer, and B. G. Hoebel. “Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.” Brain Res 550, no. 2 (June 7, 1991): 287–90. https://doi.org/10.1016/0006-8993(91)91330-4.

Rada P, Mark GP, Vitek MP, Mangano RM, Blume AJ, Beer B, et al. Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res. 1991 Jun 7;550(2):287–90.

Rada, P., et al. “Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.” Brain Res, vol. 550, no. 2, June 1991, pp. 287–90. Pubmed, doi:10.1016/0006-8993(91)91330-4.

Rada P, Mark GP, Vitek MP, Mangano RM, Blume AJ, Beer B, Hoebel BG. Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res. 1991 Jun 7;550(2):287–290.