Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.

Journal Article (Journal Article)

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute response in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1 beta (7.5-50 micrograms/kg) decreased extracellular acetylcholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

Full Text

Duke Authors

Cited Authors

  • Rada, P; Mark, GP; Vitek, MP; Mangano, RM; Blume, AJ; Beer, B; Hoebel, BG

Published Date

  • June 7, 1991

Published In

Volume / Issue

  • 550 / 2

Start / End Page

  • 287 - 290

PubMed ID

  • 1884236

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(91)91330-4


  • eng

Conference Location

  • Netherlands