Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.

Journal Article

Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD). Regulation of expression at the transcriptional and posttranscriptional levels contributes significantly to these increases. Polypeptide hormones stimulate the promoter of the APP gene resulting in increased levels of heterogeneous nuclear RNAs (hnRNA). Through splicing, these hnRNAs are processed into 3 or more mature APP RNAs. The amounts of each of these similar but nonidentical APP RNAs may yield ratios of APP proteins which are required for neuronal survival, pathogenesis of neurons and/or produce phenocopies of learning and memory mutants of Drosophila.

Full Text

Duke Authors

Cited Authors

  • Vitek, MP

Published Date

  • September 1989

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 471 - 473

PubMed ID

  • 2510042

International Standard Serial Number (ISSN)

  • 0197-4580

Language

  • eng

Conference Location

  • United States