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Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.

Publication ,  Journal Article
Fales, AM; Yuan, H; Vo-Dinh, T
Published in: Langmuir : the ACS journal of surfaces and colloids
October 2011

This paper reports the synthesis and characterization of surface-enhanced Raman scattering (SERS) label-tagged gold nanostars, coated with a silica shell containing methylene blue photosensitizing drug for singlet-oxygen generation. To our knowledge, this is the first report of nanocomposites possessing a combined capability for SERS detection and singlet-oxygen generation for photodynamic therapy. The gold nanostars were tuned for maximal absorption in the near-infrared (NIR) spectral region and tagged with a NIR dye for surface-enhanced resonance Raman scattering (SERRS). Silica coating was used to encapsulate the photosensitizer methylene blue in a shell around the nanoparticles. Upon 785 nm excitation, SERS from the Raman dye is observed, while excitation at 633 nm shows fluorescence from methylene blue. Methylene-blue-encapsulated nanoparticles show a significant increase in singlet-oxygen generation as compared to nanoparticles synthesized without methylene blue. This increased singlet-oxygen generation shows a cytotoxic effect on BT549 breast cancer cells upon laser irradiation. The combination of SERS detection (diagnostic) and singlet-oxygen generation (therapeutic) into a single platform provides a potential theranostic agent.

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Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

October 2011

Volume

27

Issue

19

Start / End Page

12186 / 12190

Related Subject Headings

  • Surface Properties
  • Spectrum Analysis, Raman
  • Singlet Oxygen
  • Silicon Dioxide
  • Photochemotherapy
  • Particle Size
  • Metal Nanoparticles
  • Humans
  • Gold
  • Fluorescent Dyes
 

Citation

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Fales, A. M., Yuan, H., & Vo-Dinh, T. (2011). Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. Langmuir : The ACS Journal of Surfaces and Colloids, 27(19), 12186–12190. https://doi.org/10.1021/la202602q
Fales, Andrew M., Hsiangkuo Yuan, and Tuan Vo-Dinh. “Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.Langmuir : The ACS Journal of Surfaces and Colloids 27, no. 19 (October 2011): 12186–90. https://doi.org/10.1021/la202602q.
Fales AM, Yuan H, Vo-Dinh T. Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. Langmuir : the ACS journal of surfaces and colloids. 2011 Oct;27(19):12186–90.
Fales, Andrew M., et al. “Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 27, no. 19, Oct. 2011, pp. 12186–90. Epmc, doi:10.1021/la202602q.
Fales AM, Yuan H, Vo-Dinh T. Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. Langmuir : the ACS journal of surfaces and colloids. 2011 Oct;27(19):12186–12190.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

October 2011

Volume

27

Issue

19

Start / End Page

12186 / 12190

Related Subject Headings

  • Surface Properties
  • Spectrum Analysis, Raman
  • Singlet Oxygen
  • Silicon Dioxide
  • Photochemotherapy
  • Particle Size
  • Metal Nanoparticles
  • Humans
  • Gold
  • Fluorescent Dyes