Activity of psoralen-functionalized nanoscintillators against cancer cells upon X-ray excitation.
Published
Journal Article
We report development of a nanoparticle-based, X-ray-activated anticancer "nanodrug" composed of yttrium oxide (Y(2)O(3)) nanoscintillators, a fragment of the HIV-1 TAT peptide, and psoralen. In this formulation, X-ray radiation is absorbed by the Y(2)O(3) nanoscintillators, which then emit UVA light. Absorption of UVA photons by nanoparticle-tethered psoralen has the potential to cross-link adenine and thymine residues in DNA. UVA-induced cross-linking by free psoralen upon activation with UVA light has previously been shown to cause apoptosis in vitro and an immunogenic response in vivo. Studies using the PC-3 human prostate cancer cell line demonstrate that X-ray excitation of these psoralen-functionalized Y(2)O(3) nanoscintillators yields concentration-dependent reductions in cell number when compared to control cultures containing psoralen-free Y(2)O(3) nanoscintillators.
Full Text
Duke Authors
Cited Authors
- Scaffidi, JP; Gregas, MK; Lauly, B; Zhang, Y; Vo-Dinh, T
Published Date
- June 2011
Published In
Volume / Issue
- 5 / 6
Start / End Page
- 4679 - 4687
PubMed ID
- 21553850
Pubmed Central ID
- 21553850
Electronic International Standard Serial Number (EISSN)
- 1936-086X
International Standard Serial Number (ISSN)
- 1936-0851
Digital Object Identifier (DOI)
- 10.1021/nn200511m
Language
- eng