Activity of psoralen-functionalized nanoscintillators against cancer cells upon X-ray excitation.
We report development of a nanoparticle-based, X-ray-activated anticancer "nanodrug" composed of yttrium oxide (Y(2)O(3)) nanoscintillators, a fragment of the HIV-1 TAT peptide, and psoralen. In this formulation, X-ray radiation is absorbed by the Y(2)O(3) nanoscintillators, which then emit UVA light. Absorption of UVA photons by nanoparticle-tethered psoralen has the potential to cross-link adenine and thymine residues in DNA. UVA-induced cross-linking by free psoralen upon activation with UVA light has previously been shown to cause apoptosis in vitro and an immunogenic response in vivo. Studies using the PC-3 human prostate cancer cell line demonstrate that X-ray excitation of these psoralen-functionalized Y(2)O(3) nanoscintillators yields concentration-dependent reductions in cell number when compared to control cultures containing psoralen-free Y(2)O(3) nanoscintillators.
Duke Scholars
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Related Subject Headings
- tat Gene Products, Human Immunodeficiency Virus
- Yttrium
- X-Rays
- Thymine
- Prostatic Neoplasms
- PUVA Therapy
- Nanotechnology
- Nanoscience & Nanotechnology
- Male
- Humans
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- tat Gene Products, Human Immunodeficiency Virus
- Yttrium
- X-Rays
- Thymine
- Prostatic Neoplasms
- PUVA Therapy
- Nanotechnology
- Nanoscience & Nanotechnology
- Male
- Humans