Plasmonic nanoprobes for SERS biosensing and bioimaging.

Journal Article (Review;Journal Article)

This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface-enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface-enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye-labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using "molecular sentinel" nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Wang, H-N; Scaffidi, J

Published Date

  • January 2010

Published In

Volume / Issue

  • 3 / 1-2

Start / End Page

  • 89 - 102

PubMed ID

  • 19517422

Pubmed Central ID

  • PMC4022302

Electronic International Standard Serial Number (EISSN)

  • 1864-0648

International Standard Serial Number (ISSN)

  • 1864-063X

Digital Object Identifier (DOI)

  • 10.1002/jbio.200910015


  • eng