Plasmonic nanoprobes for SERS biosensing and bioimaging.


Journal Article (Review)

This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface-enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface-enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye-labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using "molecular sentinel" nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Wang, H-N; Scaffidi, J

Published Date

  • January 2010

Published In

Volume / Issue

  • 3 / 1-2

Start / End Page

  • 89 - 102

PubMed ID

  • 19517422

Pubmed Central ID

  • 19517422

Electronic International Standard Serial Number (EISSN)

  • 1864-0648

International Standard Serial Number (ISSN)

  • 1864-063X

Digital Object Identifier (DOI)

  • 10.1002/jbio.200910015


  • eng