Development of a DNA biochip: Principle and applications
This paper provides an overview of the operating principle of a DNA biochip based on integrated circuit for use in biomedical diagnostics. The device is a self-contained system with photosensors, amplifiers, discriminators and logic circuitry on board. The development and evaluation of various microchip system components of the genosensor are reviewed. Fluorescence detection of gene probes specific to DNA sequences related to pathogens such as the human immuno-deficiency virus 1 (HIV1) system illustrates the usefulness and potential of the DNA biochip technology for rapid and cost-effective medical diagnostics. Potential usefulness of the DNA biochip in clinical applications and functional genomics research is discussed. © 1998 Elsevier Science S.A. All rights reserved.
Duke Scholars
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- Analytical Chemistry
- 4016 Materials engineering
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0912 Materials Engineering
- 0301 Analytical Chemistry
- 0205 Optical Physics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Analytical Chemistry
- 4016 Materials engineering
- 4004 Chemical engineering
- 3401 Analytical chemistry
- 0912 Materials Engineering
- 0301 Analytical Chemistry
- 0205 Optical Physics