Development of a DNA biochip: Principle and applications

Journal Article (Journal Article)

This paper provides an overview of the operating principle of a DNA biochip based on integrated circuit for use in biomedical diagnostics. The device is a self-contained system with photosensors, amplifiers, discriminators and logic circuitry on board. The development and evaluation of various microchip system components of the genosensor are reviewed. Fluorescence detection of gene probes specific to DNA sequences related to pathogens such as the human immuno-deficiency virus 1 (HIV1) system illustrates the usefulness and potential of the DNA biochip technology for rapid and cost-effective medical diagnostics. Potential usefulness of the DNA biochip in clinical applications and functional genomics research is discussed. © 1998 Elsevier Science S.A. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T

Published Date

  • August 31, 1998

Published In

Volume / Issue

  • 51 / 1-3

Start / End Page

  • 52 - 59

International Standard Serial Number (ISSN)

  • 0925-4005

Digital Object Identifier (DOI)

  • 10.1016/S0925-4005(98)00182-8

Citation Source

  • Scopus