Surface-enhanced Raman gene probes.

Journal Article (Journal Article)

We report for the first time a new type of DNA gene probe based on surface-enhanced Raman scattering (SERS) label detection. The surface-enhanced Raman gene (SERG) probes do not require the use of radioactive labels and have great potential to provide both sensitivity and selectivity. The SERG probe can be used to detect DNA biotargets (e.g., gene sequences, bacteria, viral DNA fragments) via hybridization to DNA sequences complementary to that probe. The analytical figures of merit and its applications in environmental and biomedical areas are discussed.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Houck, K; Stokes, DL

Published Date

  • October 1994

Published In

Volume / Issue

  • 66 / 20

Start / End Page

  • 3379 - 3383

PubMed ID

  • 7978314

Electronic International Standard Serial Number (EISSN)

  • 1520-6882

International Standard Serial Number (ISSN)

  • 0003-2700

Digital Object Identifier (DOI)

  • 10.1021/ac00092a014


  • eng