The dynamics of death in prostate cancer.

Journal Article

The hazard function provides the instantaneous probability of death (or other key end point) at various times after diagnosis. Unlike the survival curve, the hazard function illustrates graphically or through calculations when deaths are common or uncommon. In this study, hazard functions were derived for prostate cancer by using survival data on large numbers of patients with prostate cancer with data in the Surveillance, Epidemiology and End Results (SEER) database. The results demonstrate a form of prostate cancer that rapidly evolves to cause death within 5 years, and this form of tumor is only partly identified by routine prognostic variables such as serum prostate-specific antigen (PSA) level, histologic grade, and quantity of tumor. The results also validate the presence of a reservoir of nonfatal prostate cancers that have increased rapidly during the PSA era, and they demonstrate that the incidence of fatal prostate cancers has declined.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT

Published Date

  • June 2012

Published In

Volume / Issue

  • 137 / 6

Start / End Page

  • 957 - 962

PubMed ID

  • 22586055

Pubmed Central ID

  • 22586055

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

Digital Object Identifier (DOI)

  • 10.1309/AJCPJK9V9LUMUETV


  • eng

Conference Location

  • England