Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue.


Journal Article

AIMS: Predicting prostatic cancer patients' outcome is a major objective for clinicians and patients. Several nomograms are currently implemented prior to treatment to help predict clinical and pathological outcome. The aim of this study was to investigate the prognostic significance of morphometric measurements of cancer on the needle biopsy specimen in relation to the final pathological stage or the biochemical failure status following radical prostatectomy, and to determine which measurement of tumour length in cases with discontinuous foci of cancer (DFC) is most reliably reflective of the pathological stage. METHODS AND RESULTS: Of the 100 patients included in this study, 34% had high-stage disease (pT >or= 3 and/or pN1) and 16% experienced biochemical recurrence. The analysis showed that fraction of positive cores, total percentage of cancer and both total and greatest millimetric cancer lengths were the variables most closely associated with pathological stage and biochemical failure status. CONCLUSIONS: This study confirms the prognostic value of recording tumour extent in prostatic needle biopsy reporting. However, the results are inconclusive in determining the best method to record tumour length in cores with DFC and larger studies are needed to answer this question fully.

Full Text

Duke Authors

Cited Authors

  • Brimo, F; Vollmer, RT; Corcos, J; Kotar, K; Bégin, LR; Humphrey, PA; Bismar, TA

Published Date

  • August 2008

Published In

Volume / Issue

  • 53 / 2

Start / End Page

  • 177 - 183

PubMed ID

  • 18752501

Pubmed Central ID

  • 18752501

Electronic International Standard Serial Number (EISSN)

  • 1365-2559

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2559.2008.03087.x


  • eng

Conference Location

  • England